D80.1: Nonfamilial hypogammaglobulinaemia

Your immune system is not producing enough antibodies.

The immune system protects the body from pathogens and foreign substances. The immune system can also destroy cells in the body that have pathologically changed. The body's immune system is made up of different types of immune cells. Some immune cells can destroy pathogens or foreign bodies themselves. Other immune cells produce certain antibodies. Some of the immune system’s antibodies can make pathogens and foreign substances visible to the immune system. Other antibodies attack pathogens or foreign substances directly.

There can be various reasons for not producing enough antibodies. These include genetic changes, certain drugs and various illnesses.

If you are not producing enough antibodies, you will be unable to properly combat various pathogens. Pathogens include bacteria, viruses and fungi, for example. The pathogens can repeatedly cause infection. The infections can affect the respiratory tract or the skin, for example. The infections may also be more severe and last longer than normal.

Additional indicator

On medical documents, the ICD code is often appended by letters that indicate the diagnostic certainty or the affected side of the body.

  • G: Confirmed diagnosis
  • V: Tentative diagnosis
  • Z: Condition after
  • A: Excluded diagnosis
  • L: Left
  • R: Right
  • B: Both sides

Further information


This information is not intended for self-diagnosis and does not replace professional medical advice from a doctor. If you find an ICD code on a personal medical document, please also note the additional indicator used for diagnostic confidence.
Your doctor will assist you with any health-related questions and explain the ICD diagnosis code to you in a direct consultation if necessary.


Provided by the non-profit organization “Was hab’ ich?” gemeinnützige GmbH on behalf of the Federal Ministry of Health (BMG).